Combating Infections: Oral Health to Overall Health

Microbial resistance is a major health challenge across the globe due to increasing number of antibiotics are no longer effective in treating infections. Our group has been investigating routes to develop peptide-based strategies to combat infections. We work on antimicrobial peptides (AMPs) as a novel therapeutic modality to treat infection, partly due to their inhibition activity against a range of microorganisms. Utilizing data mining, machine learning and bioinformatics tools combined with the structure-function relationships, we have been modifying as well as designing antimicrobial peptides and developing novel local delivery systems to the sites ranging from implants to adhesive tissue interfaces systems.